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Rabbit Anti-CRBN/Cy5 Conjugated antibody (bs-11716R-Cy5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-11716R-Cy5
英文名称 Anti-CRBN/Cy5
中文名称 Cy5标记的cereblon蛋白抗体
别    名 Cereblon; DKFZp781K0715; MGC27358; MRT2A; OTTHUMP00000209555; piL; Protein cereblon; Protein x 0001; 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; CRBN_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRBN (210-288aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation.

Function:
Protein cereblon modulates cell surface expression of KCNT1 and may be involved in memory and learning. It is highly expressed in brain and defects in CRBN are the cause of non syndromic mental retardation autosomal recessive type 2A (MRT2A) [MIM:607417]. Although it contains a Lon domain also found in proteases of the peptidase S16 family, it does not contain the ATP binding and catalytic domains, suggesting that it has no protease activity.

Subunit:
Interacts with KCNT1 (By similarity). Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1.

Subcellular Location:
Cytoplasm. Nucleus. Membrane; Peripheral membrane protein

Tissue Specificity:
Widely expressed. Highly expressed in brain.

Post-translational modifications:
Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex.

DISEASE:
Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A) [MIM:607417]. MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs.

Similarity:
Belongs to the CRBN family.
Contains 1 Lon domain.

Database links:

Entrez Gene: 51185 Human

Entrez Gene: 58799 Mouse

Entrez Gene: 297498 Rat

Entrez Gene: 445491 Zebrafish

GenBank: NM_016302.2 Human

Omim: 607417 Human

SwissProt: Q96SW2 Human

SwissProt: Q8C7D2 Mouse

SwissProt: Q56AP7 Rat

SwissProt: Q68EH9 Zebrafish

Unigene: 18925 Human

Unigene: 290085 Mouse

Unigene: 195259 Rat

Unigene: 84847 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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